Scientific Publications
Discover our contributions to research in molecular biology and applied biochemistry
Targeting RNA-binding proteins with small molecules: Perspectives and Challenges
Olivier Mpungi Konde, Williams Balela Balela, Tania Bishola Tshitenge
Frontiers in Chemistry
This review examines the prospects and challenges of targeting RNA-binding proteins with small molecules, opening new therapeutic avenues.
Keywords :
RNA binding proteins small molecules therapeutic molecular targeting
DOI: 10.3389/fchem.2025.1649692
Phytochemical screening, UPLC analysis, evaluation of synergistic antioxidant and antibacterial efficacy of three medicinal plants used in Kinshasa, DR Congo
Lyz Makwela Ngolo, Odette Kabena Ngandu, Paulin Mutwale Kapepula, Sephora Mianda Mutombo, Tania Bishola Tshitenge
Scientific Reports, Vol. 15, pp. 1-14 (2025)
This study presents the phytochemical screening, UPLC analysis and evaluation of the synergistic antioxidant and antibacterial efficacy of three medicinal plants used in Kinshasa, DR Congo.
Keywords :
phytochemistry UPLC antioxidant antibacterial medicinal plants
DOI: 10.1038/s41598-025-94301-w
Application of Generative Adversarial Networks on RNASeq data to uncover COVID-19 severity biomarkers
Yvette K. Kalimumbalo, Rosaline W. Macharia, Peter W. Wagacha
Advances in Biomarker Sciences and Technology 7, pp. 44–58 (2025)
This research focuses on identifying biomarkers of COVID-19 severity from RNA-Seq data analyzed using artificial intelligence approaches. The authors use generative adversarial networks (GANs) to increase the size of limited datasets, thereby improving the robustness of machine learning models.
Keywords :
COVID-19 GANs Neutrophil degranulation Cilium assembly Biomarkers
DOI: 10.1016/j.abst.2025.01.002
The Trypanosoma brucei RNA-binding protein DRBD18 ensures correct mRNA trans-splicing and polyadenylation patterns
Tania Bishola Tshitenge, Christine Clayton
RNA, Vol. 28, p. 1239-1262 (2022)
This study presents the phytochemical screening, UPLC analysis and evaluation of the synergistic antioxidant and antibacterial efficacy of three medicinal plants used in Kinshasa, DR Congo.
Keywords :
phytochemistry UPLC antioxidant antibacterial medicinal plants
DOI: 10.1261/rna.079258.122
Several different sequences are involved in bloodstream-form-specific gene expression in Trypanosoma brucei
Tania Bishola Tshitenge, Lena Reichert, Bin Liu, Christine Clayton
PLoS Negl Trop.p Dis 16(3) (2021)
This paper focuses on the regulation of gene expression in the parasite Trypanosoma brucei, responsible for sleeping sickness.
He seeks to understand how certain proteins (RBP10 and PGKC) are only expressed in the infectious form of the parasite (blood form) and are repressed in the procyclic form (in the tsetse fly).
Keywords :
phytochemistry Trypanosoma brucei Post-transcriptional regulation mRNA / 3'-UTR (untranslated region) RNA-binding protein (RBP10) Phosphoglycerate kinase (PGKC)
DOI: 10.1261/rna.079258.122
Interactions of the Trypanosoma brucei brucei zinc-finger-domain protein ZC3H28
Tania Bishola Tshitenge, Christine Clayton
Parasitology,149,pp. 356–370 (2021)
This article investigates the role of the RNA-binding protein ZC3H28 in Trypanosoma brucei, a parasite responsible for sleeping sickness.
It shows that, as in other kinetoplastids, regulation of gene expression in T. brucei occurs mainly after transcription, through RNA-binding proteins.
Keywords :
mRNA decay; RNA-binding proteins; translation; Trypanosoma brucei